In 2022,Kumar Ghosh, Asim; Neogi, Sukanya; Das, Krishna Kanta; Hajra, Alakananda published an article in Journal of Organic Chemistry. The title of the article was 《Organocatalytic Oxidative C-H Amination of Aldehyde Hydrazones with Azoles at Ambient Temperature》.Safety of 1H-1,2,3-Triazole The author mentioned the following in the article:
An efficient, metal-free, and direct oxidative amination of aldehyde-derived hydrazones R1CH=N-N(CH2)2X(CH2)2- (R1 = Ph, 2-bromo-5-chlorophenyl, naphthalen-1-yl, 2-methylphenyl, etc.; X = O, CH2) with azoles e.g., I has been developed using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as an organocatalyst under ambient temperature This protocol provides a wide range of aminated hydrazone derivatives II (R2 = 3,5-dimethyl-1H-pyrazol-1-yl, 2H-indazol-2-yl, 4-phenyl-1H-1,2,3-triazol-1-yl, etc.) in a step and atom economical fashion. The reaction possibly follows a radical mechanism.1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole) was used in this study.
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics