Kume, Masaharu’s team published research in Journal of Antibiotics in 46 | CAS: 59032-27-8

Journal of Antibiotics published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C2H2N3NaS, Application In Synthesis of 59032-27-8.

Kume, Masaharu published the artcileOrally active cephalosporins. II. Synthesis and structure-activity relationships of new 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]cephalosporins with 1,2,3-triazole in C-3 side chain, Application In Synthesis of 59032-27-8, the publication is Journal of Antibiotics (1993), 46(1), 177-92, database is CAplus and MEDLINE.

The synthesis, antibacterial activity and oral absorbability of the title compounds I (X = CH2S(CH2)n, S(CH2)m, SCH2S(CH2)x, CH2SCH2S, S(CH2)2S, S(CH2)2O, S(CH2)2NH; n, m = 1-3, x = 0-2) are described. Their oral absorbability was influenced by the spacer length between C-3 of a cephem nucleus and C-4′ of 1,2,3-triazole. The SCH2S structure was also found to contribute to their good oral absorption. The quant. relationship between the bioavailability and the spacer length of cephalosporins is discussed.

Journal of Antibiotics published new progress about 59032-27-8. 59032-27-8 belongs to triazoles, auxiliary class Triazoles, name is Sodium 1,2,3-triazole-5-thiolate, and the molecular formula is C2H2N3NaS, Application In Synthesis of 59032-27-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics