Kung, Daniel W. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2012 | CAS: 179056-04-3

4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Synthetic Route of C9H7N3O

Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor was written by Kung, Daniel W.;Coffey, Steven B.;Jones, Ryan M.;Cabral, Shawn;Jiao, Wenhua;Fichtner, Michael;Carpino, Philip A.;Rose, Colin R.;Hank, Richard F.;Lopaze, Michael G.;Swartz, Roger;Chen, Hou;Hendsch, Zachary;Posner, Bruce;Wielis, Christopher F.;Manning, Brian;Dubins, Jeffrey;Stock, Ingrid A.;Varma, Sam;Campbell, Mary;DeBartola, Demetria;Kosa-Maines, Rachel;Steyn, Stefanus J.;McClure, Kim F.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Synthetic Route of C9H7N3O This article mentions the following:

The discovery of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor is described. The characterization and redressing of the issues associated with these compounds is detailed. An efficient three-step synthesis and a binding assay were relied upon as the primary means of rapidly improving potency and ADMET properties for this class of inverse agonist compounds Compound 10n bearing distributed polarity in the form of an imidazo-thiazole acetamide and a Ph triazole is a unit lower in log P and has significantly improved binding affinity compared to the hit mol. 10a, providing support for further optimization of this series of compounds In the experiment, the researchers used many compounds, for example, 4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3Synthetic Route of C9H7N3O).

4-(2H-1,2,3-Triazol-2-yl)benzaldehyde (cas: 179056-04-3) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Synthetic Route of C9H7N3O

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics