On February 20, 2011, Lee, Seokjoon published an article.Synthetic Route of 5301-96-2 The title of the article was Synthesis of 10β-substituted triazolyl artemisinins and their growth inhibitory activity against various cancer cells. And the article contained the following:
A library of 10-triazolylartemisinins was established comprising compounds that strongly inhibit the growth of cancer cell lines, such as DLD-1, U-87, Hela, SiHa, A172, and Bi1. These compounds were synthesized by an acid-catalyzed reaction of dihydroartemisinin (I) with various triazoles in CH2Cl2 at room temperature In particular, when 3 equivalent of triazole were reacted with I, 10β-(4-substituted triazolyl)artemisinins were obtained, which means that the type of product obtained differs according to the quantity of triazole reactant employed in the synthesis. From the viewpoint of antiproliferative activity against the various cancer cells, compounds, which have a (pentylphenyl)triazole moiety, exhibited potent activity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2
The Article related to triazolylartemisinin preparation anticancer, artemisinin triazole preparation anticancer, Terpenes and Terpenoids: Sesquiterpenes (C15), Including Ionones and other aspects.Synthetic Route of 5301-96-2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics