Product Details of 510758-28-8In 2019 ,《Stereoselective Synthesis of Molecular Square and Granny Knots》 was published in Journal of the American Chemical Society. The article was written by Leigh, David A.; Pirvu, Lucian; Schaufelberger, Fredrik. The article contains the following contents:
The authors report on the stereoselective synthesis of both mol. granny and square knots through the use of lanthanide-complexed overhand knots of specific handedness as three-crossing “”entanglement synthons””. The composite knots are assembled by combining two entanglement synthons (of the same chirality for a granny knot; of opposite handedness for a square knot) in three synthetic steps: first, a CuAAC reaction joins together one end of each overhand knot. Ring-closing olefin metathesis (RCM) then affords the closed-loop knot, locking the topol. This allows the lanthanide ions necessary for stabilizing the entangled conformation of the synthons to subsequently be removed. The composite knots were characterized by 1H and 13C NMR spectroscopy and mass spectrometry and the chirality of the knot stereoisomers compared by CD. The synthetic strategy of combining building blocks of defined stereochem. (here overhand knots of Λ- or Δ-handed entanglement) is reminiscent of the chiron approach of using minimalist chiral synthons in the stereoselective synthesis of mols. with multiple asym. centers. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics