On December 31, 2016, Li, Xiaolong; He, Yun; Hai, Li; Zhang, Tao; Wu, Yong published an article.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was A Novel Method to Synthesize 4-Aryl-1H-1,2,3-Triazoles and their Antihepatoma Activity. And the article contained the following:
A novel method for the preparation of 4-aryl-1H-1,2,3-triazoles (I) (aryl = R = Ph, 4-MeC6H4, 4-Cl-3-F3CC6H3, 4-morpholinyl-3-F3CC6H3, 4-piperidinyl-3-F3CC6H3, etc.) from arylglyoxaldoxime semicarbazones HON:CHCR:NNHC(O)NH2 with sodium dithionite and O2 was developed and found to be safer than the Huisgen azide-alkyne dipolar cycloaddition A total of 17 new 4-aryl-1H-1,2,3-triazoles were prepared and characterized by 1H NMR, 13C NMR and ESI-MS. Subsequently, their in-vitro antihepatoma activities were evaluated on human hepatoma QGY-7703, Bel-7402 and SMMC-7721 cell lines and mouse fibroblast cells L-929 by MTS assay. Among them, I (R = 4-Cl-3-F3CC6H3) exhibited excellent activity against QGY-7703 (GI50 = 0.0232 μM), while I (R = 4-morpholinyl-3-F3CC6H3, 4-piperidinyl-3-F3CC6H3) displayed good activity (GI50 = 0.103 μM and GI50 = 0.182 μM, resp.) against the growth of SMMC-7721 cell lines. Furthermore, these three triazoles showed slight selectivity of inhibition of hepatoma cell lines over normal cell line L-929. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole
The Article related to glyoxaldoxime semicarbazone aryl preparation cyclization, triazole aryl preparation antihepatoma activity, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics