The author of 《Functionalization of luminescent lanthanide-gallium metallacrowns using copper-catalyzed alkyne-azide cycloaddition and thiol-maleimide Michael addition》 were Lutter, Jacob C.; Lopez Bermudez, Beatriz A.; Nguyen, Tu N.; Kampf, Jeff W.; Pecoraro, Vincent L.. And the article was published in Journal of Inorganic Biochemistry in 2019. HPLC of Formula: 510758-28-8 The author mentioned the following in the article:
The synthesis and characterization of {Ln[12-MCIIIGaIIIN(eshi)-4]}2(iph)4 and {Ln[12-MCIIIGaIIIN(shi)-4]}2(miph)4 metallacrowns (MCs), where shi3- is salicylhydroximate, eshi3- is 4-ethynylsalicylhydroximate, iph2- is isopthalate, and miph2- is 5-maleimidoisophthalate, is reported. The ethynyl functionality allows for coupling of MCs to azides using copper(I) catalyzed alkyne-azide cycloaddition (CuAAC), while the maleimido functionality allows for coupling of the MCs to thiol-bearing compounds The authors demonstrate these coupling reactions using benzyl azide for the former and cysteamine for the latter, with complete conversion shown by ESI-MS. With the Sm analogs, the MCs exhibit characteristic luminescent emission of Sm(III), which is preserved after introducing the ethynyl and maleimido groups onto the MC scaffold. Furthermore, the high stability of these compounds in solution illustrates that once functionalized, the MCs are promising for fluorescent imaging applications. In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8HPLC of Formula: 510758-28-8)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.HPLC of Formula: 510758-28-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics