Ma, Dong; Yin, Yang; Chen, Ying-Lu; Yan, Yi-Tao; Wu, Jun published an article in 2021. The article was titled 《Design, step-economical diversity-oriented synthesis of an N-heterocyclic library containing a pyrimidine moiety: discovery of novel potential herbicidal agents》, and you may find the article in RSC Advances.Application of 288-36-8 The information in the text is summarized as follows:
The step-economical diversity-oriented synthesis of a library of various pyrimidine-N-heterocycle hybrids I [R = 1H-imidazol-1-yl, 1H-1,2,3-triazol-1-yl, 1-methyl-1H-indol-3-yl, etc.] and II [R1 = 5-Me, 4-Cl, 5-Cl, 6-Cl] was developed, in which a 4,6-dimethoxypyrimidine core was incorporated into nine kinds of N-heterocycles. A total of 34 structurally diverse compounds I and II were synthesized via a two-step process from very simple and com. available starting materials. Further, in-vivo biol. screening of this library identified 11 active compounds I [R = 1H-imidazol-1-yl, 1H-1,2,3-triazol-1-yl, 2-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl, 3-methyl-1H-indazol-1-yl, 5-methyl-1H-indazol-1-yl, 2,3,4,9-tetrahydro-1H-carbazol-9-yl, 1H-indol-3-yl, 4-chloro-1H-indol-3-yl, 5-chloro-1H-indol-3-yl, 7-chloro-1H-indol-3-yl] and II [R1 = 5-Cl] that exhibited good post-emergence herbicidal activity against D. sanguinalis at 750 g ai per ha. More importantly, pyrimidine-tetrahydrocarbazole hybrid I [R = 2,3,4,9-tetrahydro-1H-carbazol-9-yl] showed good to excellent herbicidal activity against five test weeds at the same dosage. Pyrimidine-tetrahydrocarbazole hybrids I [R = 9H-carbazol-9-yl, 2,3,4,9-tetrahydro-1H-carbazol-9-yl, 3-chloro-9H-carbazol-9-yl] represented a novel class of herbicidal agents that may become promising lead compounds in the herbicidal discovery process.1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8) was used in this study.
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics