Maw, Graham N. published the artcileThe discovery of small molecule inhibitors of neutral endopeptidase. Structure-activity studies on functionalized glutaramides, Product Details of C2H2N4O2, the publication is Chemical Biology & Drug Design (2006), 67(1), 74-77, database is CAplus and MEDLINE.
A series of small mol. glutaramides were synthesized and evaluated for potency against canine and human neutral endopeptidase using target criteria of mol. weight <400 and log P between 2 and 4.5 to maximize the likelihood of achieving good oral absorption. The activity of a prototype compound, chiral (2R)-2-[[1-[[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]carbonyl]cyclopentyl]methyl]pentanoic acid was reported. The structure-activity relationship (SAR) investigations described in this paper led to the identification of an Et 1,3,4-thiadiazole glutaramide which demonstrated good neutral endopeptidase potency, selectivity and excellent oral absorption in the rat.
Chemical Biology & Drug Design published new progress about 14544-45-7. 14544-45-7 belongs to triazoles, auxiliary class Triazoles, name is 5-Nitro-1H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Product Details of C2H2N4O2.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics