On March 18, 2021, Mitsiades, Constantine S.; Shirasaki, Ryosuke; Matthews, Geoffrey M.; Gandolfi, Sara; De Matos Simoes, Ricardo published a patent.Formula: C49H60ClN9O7S2 The title of the patent was Methods for treating cancer using serial administration of E3 ubiquitin ligase degraders. And the patent contained the following:
The present invention relates, in part, to methods for treating cancer using serial administration of E3 ubiquitin ligase degraders. The experimental process involved the reaction of (2S,4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide(cas: 1949837-12-0).Formula: C49H60ClN9O7S2
The Article related to e3 ubiquitin ligase degrader cancer therapy, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Formula: C49H60ClN9O7S2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics