Mittapelli, Vasantha published the artcileIsolation/synthesis & characterization & potential impurities of antifungal drug, Fluconazole, Quality Control of 86386-77-8, the publication is Asian Journal of Biochemical and Pharmaceutical Research (2011), 1(4), 201-206, database is CAplus.
In the synthesis of Fluconazole in bulk [α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol] various impurities are formed. The synthesis of the target compounds was achieved by a literature synthesis or using fluconazole as a starting material. The present work details the isolation/synthesis and characterization of isomer impurity, triazole impurity and desfluoro impurity [i.e., α-(4-fluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol].
Asian Journal of Biochemical and Pharmaceutical Research published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Quality Control of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics