In an article, author is Kaur, Ramandeep, once mentioned the application of 464-48-2, Recommanded Product: 464-48-2, Name is (-)-Camphor, molecular formula is C10H16O, molecular weight is 152.2334, MDL number is MFCD00064148, category is Triazoles. Now introduce a scientific discovery about this category.
Synthesis and studies of thiazolidinedione-isatin hybrids as alpha-glucosidase inhibitors for management of diabetes
Aim: Keeping in view the side effects associated with clinically used alpha-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures. Materials & methods: Biological evaluation, cytotoxicity assessment, molecular docking, binding free energy calculations and molecular dynamics studies were performed for hybrids. Results: The most potent inhibitor A-10 (IC50 = 24.73 +/- 0.93 mu M) was competitive in manner and observed as non-cytotoxic. A-10 possessed higher efficacy than the standard drug (acarbose) during in vivo biological testing. Conclusion: The enzyme inhibitory potential and safety profile of synthetic molecules was recognized after in vitro, in vivo, in silico and cytotoxicity studies. Further structural optimization of A-10 can offer potential hit molecules suitable for future investigations.
Interested yet? Read on for other articles about 464-48-2, you can contact me at any time and look forward to more communication. Recommanded Product: 464-48-2.