On March 18, 2022, Motornov, Vladimir; Beier, Petr published an article.Formula: C9H9N3 The title of the article was Access to Fluoroalkylated Azoles and 2-Acylaminoketones via Fluorinated Anhydride-Mediated Cleavage of NH-1,2,3-Triazoles. And the article contained the following:
NH-1,2,3-Triazoles I (R = Ph, 2-chlorophenyl, cyclohex-1-enyl, etc.; R1 = H, CH3, C2H5, C6H5, (CH2)2C(O)2CH3, Cl) undergo a ring cleavage in reactions with fluorinated acid anhydrides (trifluoroacetic, trichloroacetic, difluoroacetic, chlorodifluoroacetic and pentafluoropropionic anhydrides) by nitrogen acylation and acid-mediated triazole ring opening. Structurally diverse fluoroalkylated oxazoles II (X = H, F, Cl, CF3) were prepared from 4,5-disubstituted-1,2,3-triazoles I. Efficient synthesis of 2-acylaminoketones RC(O)CH2NHC(O)CF2X and 2,2,2-trichloro-N-(2-oxo-2-(p-tolyl)ethyl)acetamide was achieved from 4-substituted-1,2,3-triazoles I (R1 = H). Finally, easy access to fluoroalkylated imidazoles III (R2 = 4-methylphenyl, 4-chlorophenyl, 4-methoxyphenyl; R3 = Me, n-Bu; R4 = CF3, CF2CF3) and 1,2,4-triazines IV was developed by a one-pot two step route from NH-triazoles, fluorinated anhydrides and amines such as methanamine and butanamine or hydrazine, resp. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Formula: C9H9N3
The Article related to fluoroalkyl oxazole preparation, acylaminoketone preparation, imidazole fluoroalkyl preparation, trifluoromethyl triazine preparation, triazole acid anhydride acylation ring opening and other aspects.Formula: C9H9N3
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics