Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 151899-62-6, name is 3-Iodo-1-trityl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles
Nitrogen gas was bubbled through a solution of 3-iodo-l-trityl-lH-l,2,4-triazole (37.3g, 85.35mmol), and triethylamine (17.8ml, 128mmol) in anhydrous DMF (300ml) heated at 350C for 30 mins. Pd(PPh3)2Cl2 (2Ag, 3.4mmol) and CuI (651mg, 3.4mmol) were added followed by addition of ethynyltrimethylsilane (18ml, 128mmol) in anhydrous DMF (18ml) over 5 15 hours via syringe pump. After complete addition the mixture was heated at 350C for a further 5 hours. The mixture was poured into water (700ml) and extracted with EtOAc (3 x 300ml). Combined EtOAc layers washed with water (2 x 500ml), sat. NaCl (250ml), dried over Na2SO4, filtered and evaporated. The residue was purified by MPLC on silica gel eluting with a gradient from 100% hexanes to 10% EtOAc in hexanes to afford the title compound. 1HNMR (500 MHz, 10 CDCl3) delta: 7.96 (s, IH), 7.37 (m, 9H), 7.14 (m, 6H), 0.27 (s, 9H).
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 151899-62-6
Reference:
Patent; MERCK & CO., INC.; WO2008/57336; (2008); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics