Application of 16681-70-2, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
[0625] (2S,4S)-4-Amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-cyanomethylpentanoic acid ethyl ester (55 mg, 141f.tmol) was combined with 3H-[1,2,3]triazole-4-carboxylicacid (19.2 mg, 170 f.tmol), HATU (64.5 mg, 170 flillOI) andDIPEA (79 f.LL, 453 f.tmol) in DMF (2 mL) and was stirred atroom temperature for 30 minutes then concentrated in vacuo and the crude residue was purified by normal phase chromatography(0-100% EtOAc/hexanes) to yield Compound 1.55mg).
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Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics