Application of 4928-88-5, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 4928-88-5, name is Methyl 1H-1,2,4-triazole-3-carboxylate, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
In a 250 mL four-necked flask equipped with a mechanical stirrer, thermometer and distillation apparatus, 100.0 g of tetraacetyl ribose was added and heated to 100 ° C in an oil bath.After the tetraacetyl ribose is completely melted into a transparent liquid, the stirring is started.40.0 g of methyl 1,2,4-triazolecarboxylate was added, and the two materials were uniformly mixed.Add 1.4g of elemental iodine, continue to raise the temperature to 115 ° C, and keep warm for 2 hours.Then, vacuuming was started, and by-product acetic acid was distilled off; after 1 hour, the reaction was stopped, and the mixture was cooled to 70 ° C or lower, 100 mL of methanol was taken, and the mixture was added to the flask, and the mixture was stirred to uniformly dissolve the material, and poured into a beaker. Allow to cool to room temperature,Precipitate solids, filter, wash, dry,Ribavirin intermediate[1-(2,3,5-Tri-O-acetyl-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester], yield 82percent (Based on tetraacetyl ribose, the same below.)
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Reference:
Patent; Henan Academy Of Sciences High Technology Research Center; Zhang Jiaxiang; Guo Xiaozhan; Chen Tiantian; Wang Huafen; Ren Zhiyong; Gong Wei; Fu Yang; Jiang Lei; (10 pag.)CN109336937; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics