Application of 1533519-85-5, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, molecular formula is C18H17N3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Into a 1L three-necked flask, add 20.0g of intermediate (4), 80ml of tetrahydrofuran and 20ml of methanol, start stirring, warm up to 40.0C, stir until dissolved; add 20.0g NBS, 0.2g TEMPO, react for 60min; cool to 5C, add ethyl acetate 100ml and purified water 120ml, the organic phase was washed with 120ml of 3% sodium bisulfite solution and 100ml of 5% sodium bicarbonate solution, dried with anhydrous sodium sulfate 50.0g, filtered, rinsed with ethyl acetate 50ml, the mother liquor was concentrated to dryness, 60ml of ethyl acetate was added to the residue, heated until the solid was dissolved, 240ml of n-hexane was added, and the temperature was slowly lowered to 0-5C, filtered, washed, and dried to obtain 22.0g of off-white solid with a yield of 89.4%.
By the way, if you are interested in learning more fun chemistry with your kids, get your hands into one chemistry set now, and start enjoying the best part of chemistry: experiments about Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate.
Reference:
Patent; Beijing Xinkaiyuan Pharmaceutical Technology Co., Ltd. Hainan Fen Corporation; Xia Zhongning; Wu Jin; Bai Bingxin; (9 pag.)CN111116501; (2020); A;,
1,2,3-Triazole – Wikipedia,
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