Application of 16681-70-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
[0620] lH-1,2,3-triazole-4-carboxylic acid (2.6 mg, 23f.tmol) and HATU (9.6 mg, 25 f.tmol) were combined in DMF(3.0 mL) and stirred at room temperature for 15 minutes.(2S,4S)-4-Amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-[(2-methoxyethylamino)methyl]-pentanoic acid ethyl ester(10 mg, 23 flillOI) and DIPEA (12 f.LL, 69 flillOI) were addedand the resulting solution was stirred at room temperature for15 minutes, after which time LCMS indicated desired productformation. The solvent was removed in vacuo and the cruderesidue was purified by reverse phase chromatography toyield the title compound cas a TFA salt (1.2 mg). MS m/z[M+Hr calc’d for C26H31CIFN50 4 , 532.21. found 532.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics