Synthetic Route of 288-88-0, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 288-88-0, name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
General procedure: A mixture of 4-fluorobenzaldehyde (8.85 mL, 0.1 mol), the corresponding phenol, thiophenol or amine (0.1 mol), and a catalytic quantity of potassium carbonate (K2CO3) was refluxed in DMF (20 mL) for 36 h. After completion of the reaction, the mixture was poured into ice-water (50 mL), and the precipitated product was filtered, washed with deionised water, dried, and recrystallized from EtOH.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 1H-1,2,4-Triazole, hurry up and to see.
Reference:
Article; Can, Nafiz Oencue; Can, Nafiz nc; Osmaniye, Derya; Levent, Serkan; Sa Sa?lik, Beguem Nurpelin; Inci, Beril; Ilgin, Sinem; Oezkay, Yusuf; Kaplancikli, Zafer Asim; Molecules; vol. 22; 8; (2017);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics