In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7170-01-6 as follows. 7170-01-6
A mixture of 2-chloro-5-fluoropyrimidine (2.39 g, 18 mmol), 3-methyl-1H-1,2,4-triazole (1.5 g, 18 mmol), potassium carbonate (5 g, 36 mmol), potassium iodide (0.3 g, 1.8 mmol) and CH3CN (110 mL) were heated to 70 C for 18 h. The mixture was cooled to RT, diluted with CH2Cl2 (220 mL), filtered through Celite and the collected precipitate washed with CH2Cl2. The solid resulting from solvent evaporation was purified by chromatography (1-10% MeOH-CH2Cl2) and recrystallised from EtOAc to give the title compound (1.01 g, 5.64 mmol) as a colourless solid. 1H NMR (CDCl3, 300 MHz): delta 9.05 (s, 1H), 8.66 (s, 2H), 2.54 (s, 3H); LCMS (ESI) RT = 0.43 min, [M+H]+ 180.1.
According to the analysis of related databases, 7170-01-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; FAUBER, Benjamin; BODIL VAN NIEL, Monique; CRIDLAND, Andrew; HURLEY, Christopher; KILLEN, Jonathan; WARD, Stuart; (203 pag.)WO2016/177686; (2016); A1;,
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