Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, A new synthetic method of this compound is introduced below., category: Triazoles
This was made by displacing the 4-chloro phthalazine (Compound 195) with the sodium salt of 1,2, 4-triazole in DMF at55-65 C. BOCNH-P3 (L-tert-BuGly)-P2[(4R)-(4-(1, 2,4-triazo-1-yl) phthalazine-1-oxo)-S-proline]-Pl (1R,2S Vinyl Acca)-CONHSO2-Cyclopropane : the material was obtained as a white foam in 62% yield. LC/MSRt-min (MNa+) [method C]: 3.35 (774). 1H NMR (500 MHz, CD30D)8 ppm 0.97 (s, 9 H) 1. 01 (m, 2 H) 1.10 (s, 9 H) 1.16 (m,1 H) 1.37 (m, 2 H) 1.82 (m,1 H) 2.18 (d, J=8. 55 Hz,1 H) 2.32 (m,1 H) 2.69 (dd, J=13. 58,6. 87 Hz,1 H) 2.88 (br s,1 H) 4.06 (d,J=11. 60 Hz,1 H) 4.13 (s,1 H) 4.53 (m, J=9. 16 Hz,1 H) 4.61 (d,J=11. 90 Hz,1 H) 5.06 (d, J=10. 07 Hz,1 H) 5.23 (d,J=17. 40 Hz,1 H) 5.68 (m,1 H) 5.98 (s, 1 H) 7.97 (m, 2 H) 8.30 (m,J=11. 90 Hz, 2 H) 8.44 (d, J=7. 63 Hz,1 H) 9.14 (s, 1 H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99274; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics