HPLC of Formula: C2H4N4. In 2019.0 MOLECULES published article about BIOLOGICAL EVALUATION; BIS-THIAZOLES; ANTI-HCV; INHIBITORS; DESIGN; IDENTIFICATION; POTENT; AGENTS; THIADIAZOLES; COMPLEXES in [Althagafi, Ismail; El-Metwaly, Nashwa; Farghaly, Thoraya A.] Umm Al Qura Univ, Fac Sci Appl, Dept Chem, Mecca 21514, Saudi Arabia; [El-Metwaly, Nashwa] Mansoura Univ, Dept Chem, Fac Sci, Mansoura 002050, Egypt; [Farghaly, Thoraya A.] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt in 2019.0, Cited 41.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
Based on the extensive biological activities of thiazole derivatives against different types of diseases, we are interested in the effective part of many natural compounds, so we synthesized a new series of compounds containing di-, tri- and tetrathiazole moieties. The formation of such derivatives proceeded via reaction of 2-bromo-1-(4-methyl-2-(methylamino)thiazol-5-yl)ethan-1-one with heterocyclic amines, o-aminothiophenol and thiosemicarbazone derivatives. The structure and mechanistic pathways for all products were discussed and proved based on spectral results, in addition to conformational studies. Our aim after the synthesis is to investigate their antimicrobial activity against various types of bacteria and fungi species. Preceeding such an investigation, a molecular docking study was carried out with selected conformers, as representative examples, against three pathogen-proteins. This preliminary stage could support the biological application. The potency of these compounds as antimicrobial agents has been evaluated. The results showed that derivatives which have di- and trithiazole rings displayed high activity that exceeds the used standard antibiotic.
HPLC of Formula: C2H4N4. Welcome to talk about 61-82-5, If you have any questions, you can contact Althagafi, I; El-Metwaly, N; Farghaly, TA or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics