An article Microwave Assisted Three Component One-pot Synthesis of Bis(aminoazolo[1,5-a]pyrimidines) and Bis(aminoazino[1,2-a]benzimidazoles) Bearing Thiazole Moiety WOS:000491263700031 published article about DIHYDROOROTATE DEHYDROGENASE; ANTIMICROBIAL EVALUATION; BIOLOGICAL EVALUATION; BRIDGEHEAD NITROGEN; SMALL-MOLECULE; DERIVATIVES; DISCOVERY; DESIGN; BENZOTHIAZOLE; BENZIMIDAZOLE in [Mekky, Ahmed E. M.; Sanad, Sherif M. H.; Ahmed, Ahmed A. M.] Cairo Univ, Chem Dept, Fac Sci, Giza 12613, Egypt; [Ahmed, Ahmed A. M.] Jouf Univ, Sakaka, Saudi Arabia in 2019.0, Cited 55.0. Application In Synthesis of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5
Novel bis[(thiazol-2-yl)acetonitrile] derivatives were prepared in good yields by the cyclocondensation of bis(bromoacetyl) derivatives with two equivalents of 2-cyanothioacetamide in dioxane at reflux. The bis[(thiazol-2-yl)acetonitrile] derivatives were taken as synthetic precursors for the synthesis of novel bis(aminoazolo[1,5-a]pyrimidines), bearing thiazole moiety. The target molecules were prepared by the three component one pot reaction of bis[(thiazol-2-yl)acetonitrile] derivatives, dimethylformamide-dimethylacetal and several of 3-aminopyrazoles in pyridine under microwave irradiation at 140 degrees C for 2 h. Using the same protocol, novel bis(aminotriazolo[1,5-a]pyrimidines), bis(aminopyrimido[1,2-a]benzimidazoles) and bis(aminopyrido [1,2-a]benzimidazoles), incorporating thiazole moieties, were prepared by using the appropriate heterocyclic amine or 2-(1H-benzoimidazol-2-yl)acetonitrile instead of 3-aminopyrazoles. The structure of the newly prepared thiazoles was confirmed via considering their elemental analyses and spectral data.
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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics