In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103755-58-4 as follows. Safety of (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol
(l-Phenyl-lH-[l,2,3]triazol-4-yl)-methanol (700 mg) was treated with thionyl chloride (2 mL) in dichloromethane (10 mL). The mixture was stirred and heated under reflux to form a solution. The excess reagent and solvent were removed under vacuum and the residue dissolved in dichloromethane (50 mL). The dichloromethane solution was passed through a pad of silica which was further washed with dichloromethane followed by diethyl ether. The eluants were combined and concentrated to give the sub-titled compound as a solid (600 mg).1H NMR (400 MHz, CDCl3) 5 8.00 (IH, s), 7.73 – 7.68 (2H, m), 7.54 – 7.48 (2H, m), 7.47 – 7.41 (IH, m), 4.77 (2H, s).
According to the analysis of related databases, 103755-58-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB; WO2009/153536; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics