New learning discoveries about 138624-97-2

I am very proud of our efforts over the past few months and hope to 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid help many people in the next few years.

Synthetic Route of 138624-97-2, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, molecular formula is C10H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.

A mixture of 1-benzyl-1,2,4-triazole-3-carboxylic acid (16 mg, 0.08 mmol), (6S)-6-amino-2,4-dimethyl-7,8-dihydro-6H-pyrazolo[4,3-b]azepin-5-one (15 mg, 0.08 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (15 mg, 0.08 mmol) and 1-hydroxybenzotriazole (10 mg, 0.08 mmol) in N,N-dimethylformamide (5 mL) was stirred at 30 C. for 2 h. The mixture was concentrated under reduce pressure. The residue was purified by RP-HPLC (acetonitrile 22-50%/0.05% hydrochloride acid in water) to afford 1-benzyl-N-[(6S)-2,4-dimethyl-5-oxo-7,8-dihydro-6H-pyrazolo[4,3-b]azepin-6-yl]-1,2,4-triazole-3-carboxamide (16.3 mg, 56%) as a white solid. 1H NMR (400 MHz, CD3OD) delta 8.81 (s, 1H), 7.84 (s, 1H), 7.38-7.33 (m, 5H), 5.51 (s, 2H), 4.73-4.68 (m, 1H), 3.93 (s, 3H), 3.31 (s, 3H), 3.00-2.90 (m, 2H), 2.50-2.45 (m, 1H), 2.27-2.22 (m, 1H). LCMS RT=1.088 min, m/z=380.2 [M+H]+. LCMS (5 to 95% acetonitrile in water+0.03% trifluoroacetic acid over 1.5 mins) retention time 1.088 min, ESI+ found [M+H]=380.2.

I am very proud of our efforts over the past few months and hope to 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid help many people in the next few years.

Reference:
Patent; Genentech, Inc.; Patel, Snahel; Hamilton, Gregory; (73 pag.)US2018/170927; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics