Synthetic Route of 16681-70-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below.
1H-1,2,3-triazole-4-carboxylic acid (3.3 mg, 29 imol) and HATU (10.5 mg, 28 .imol) were dissolved in DMF (2.0 mL) and stirred for 15 minutes at room temperature. 2- [(R)-2-Amino-3 -(5?-chloro-2?-fluorobiphenyl-4-yl)propyl] -2-methylmalonic acid (12.0 mg, 32 .imol) and DIPEA (9.2 .iL, 53 .imol) were added, and the resulting mixture was stirred for 15 minutes at room temperature, at which time LCMS indicated the mass of the desiredcompound. The mixture was concentrated in vacuo and the residue was purified by preparative HPLC to yield the title compound (5 mg) as a TFA salt. MS m/z [M+H] calc?d for C22H20C1FN405, 475.11; found 475.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-[1,2,3]Triazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116760; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics