A common heterocyclic compound, 184177-83-1, name is 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one, molecular formula is C30H35N5O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 184177-83-1.
To a 100 ml three-necked flask was added 2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one (4.78 g) and DMSO (40 ml)Stirring dissolved, A concentration of 25 wt% aqueous NaOH (1.6 ml) was added,Mixed for 10 minutes, (5R-cis)-4-toluenesulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester (4.4 g), The mixture was reacted at 30 C for about 14 h, Liquid phase monitoring to the reaction is completed, The reaction solution was poured into vigorously stirred water (240 ml) Plus, Stir again for 10min, filter, Filter cake washed with water, The filter cake was recrystallized from isopropanol to give a solid, Dried in vacuo to give an off-white powdery solid (Formula II); By NMR, mass spectrometry and infrared spectroscopy, The gray powder solid is a compound of formula II, And the purity of the compound is 99%.
The synthetic route of 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hebei Guolong Pharmaceutical Co., Ltd.; Yan, Dianshu; Wei, Saili; Sun, Man; Yin, Jie; Liu, Yupu; Hu, Shuo; Wu, Yujie; (12 pag.)CN106366076; (2017); A;,
1,2,3-Triazole – Wikipedia,
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