Application of 288-36-8,Some common heterocyclic compound, 288-36-8, name is 1H-1,2,3-Triazole, molecular formula is C2H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under anhydrous operation, 1H-1,2,3-triazole (2.0 g, 28.9 mmol) was weighed into a 100 mL eggplant-shaped flask, and 30 mL of anhydrous THF was added.NaH (1.065 g, 43.1 mmol) was added portionwise under N2 aq ice bath and stirred at 0 C for half an hour.To the reaction system was added 2-(trimethylsilyl)ethoxymethyl chloride (SEM-Cl, 7.6 mL, 43.1 mmol).After the addition was completed, the mixture was stirred at room temperature for 10 h.The reaction was completed by TLC, quenched with water and extracted with ethyl acetate (2¡Á100 mL).The organic phases were combined, washed once with brine, dried over anhydrous sodium sulfate and evaporated.Separation using a column (petroleum ether: ethyl acetate = 10:1),3.6 g of a colorless liquid were obtained in a yield of 74.2%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-1,2,3-Triazole, its application will become more common.
Reference:
Patent; China Pharmaceutical University; Xiang Hua; Huang Ali; Wang Chong; (19 pag.)CN108707177; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics