The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Methylnicotinic acid( cas:3222-47-7 ) is researched.Reference of 6-Methylnicotinic acid.Robinson, Donovan J.; Spurlin, Sean P.; Gorden, John D.; Karimov, Rashad R. published the article 《Enantioselective Synthesis of Dihydropyridines Containing Quaternary Stereocenters Through Dearomatization of Pyridinium Salts》 about this compound( cas:3222-47-7 ) in ACS Catalysis. Keywords: dihydropyridine piperidine preparation enantioselective; pyridinium salt dearomatization rhodium BINAP catalyst. Let’s learn more about this compound (cas:3222-47-7).
Enantioselective synthesis of non-aromatic heterocycles containing a quaternary stereogenic center is a challenging synthetic problem. A strategy towards this problem involving dearomatization of N-alkylpyridinium salts using boronic acid nucleophiles have been described. This dearomatization reaction is catalyzed by Rhodium(I)/BINAP catalyst and delivers dihydropyridines that contain a fully substituted stereogenic center alpha to the ring nitrogen atom in high yield and enantioselectivity. The reaction is compatible with a wide range of functional groups such as halide, ester, amide, olefin and free alc. Derivatization of dehydropyridine products allows synthesis of the functionalized tetrahydropyridines and piperidines.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics