Synthetic Route of 40253-47-2, These common heterocyclic compound, 40253-47-2, name is Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of ethyl 3 -methyl- 1H- 1 ,2,4-triazole-5-carboxylate in anhydrous DMF was treated with sodium hydride (60 wtpercent in mineral oil, 1.2 equiv.) and stirred for 10 min. 2- Fluorobenzyl bromide (1.2 equiv.) was added. After 16 hours, water was added and the aqueous phase was extracted with ethyl acetate. The combined organic phases were washed with water and brine, dried over sodium sulfate, filtered, and the solvent was removed in vacuo. Purification by silica gel chromatography (10-50percent ethyl acetate in hexanes gradient) yielded ethyl l-(2-fluorobenzyl)-5-methyl-lH-l,2,4-triazole-3-carboxylate (58percent) and ethyl 1 -(2-fluorobenzyl)-3-methyl- 1H- 1 ,2,4-triazole-5-carboxylate (23percent)
Statistics shows that Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 40253-47-2.
Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; RENNIE, Glen Robert; PERL, Nicholas; MERMERIAN, Ara; JUNG, Joon; JIA, James; IYENGAR, Rajesh R.; IM, G-Yoon Jamie; BARDEN, Timothy Claude; SHEPPECK, James Edward; RENHOWE, Paul Allan; NAKAI, Takashi; LEE, Thomas Wai-Ho; IYER, Karthik; (346 pag.)WO2016/44446; (2016); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics