Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Methyl-1H-1,2,4-triazole
CuI (1.71 g, 8.9 mmol) and N,N’-dimethylethylenediamine (1.91 ml, 17.92 mmol) were added to a mixture of 2-amino-5-iodopyridine (5.03 g, 22.4 mmol), 3 -methyl- IH- 1,2,4- triazole (2.42 g, 29.1 mmol) and Cs2CO3 (14.60 g, 44.81 mmol) in DMF (40 ml). The r.m. was heated at 110 0C for 7 h., the r.m. was cooled, EtOAc was added and the mixure was washed with H2O. The H2O layer was extracted 5 times with EtOAc. The combined organic layers were dried (MgSO4), filtered and the solvent was evaporated in vacuo. The residue was purified by RP preparative HPLC [RP Shandon Hyperprep C18 BDS (8 mum, 250 g, LD. 5 cm); mobile phase: a gradient of (0.25 % NH4HCO3 solution in H2O)/MeOH/CH3CN]. The product fractions were collected and the solvent was evaporated. Yield: 1.5 g of intermediate 56 (38 %). –
According to the analysis of related databases, 7170-01-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; VAN BRANDT, Sven, Franciscus, Anna; BERTHELOT, Didier, Jean-Claude; WO2010/70008; (2010); A1;,
1,2,3-Triazole – Wikipedia,
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