7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C3H5N3
Synthesis of 3-methoxy-4-(3-methyl-1H-[1,2,4]triazol-1-yl)benzaldehyde A solution of 3-methyl-1H-[1,2,4]triazole [described in] (383 mg) and 4-fluoro-3-methoxybenzaldehyde (711 mg) in DMF (10 mL) was stirred at 90C overnight. Then, potassium carbonate (1.20 g) was added to the reaction solution, and the reaction solution was stirred at 110C for 6.5 hours. Water and ethyl acetate were added to the reaction solution, and the organic layer was separated. The resulting organic layer was washed with brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane-ethyl acetate system) to obtain 82.5 mg of the title compound. The property values of the compound are as follows. 1H-NMR (CDCl3) delta (ppm): 2.50 (s, 3H), 4.05 (s, 3H), 7.59 (d, J = 8.4 Hz, 1H), 7.60 (s, 1H), 8.07 (d, J = 8.4 Hz, 1H), 8.84 (s, 1H), 9.99 (s, 1H).
The synthetic route of 7170-01-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2019094; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics