Adding a certain compound to certain chemical reactions, such as: 7343-34-2, name is 3,5-Dimethyl-4H-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7343-34-2, Computed Properties of C4H7N3
Intermediate 2 4-(3,5-dimethyl-lH-l,2,4-triazol-l-yl)-6-iodo-2-methylpyrimidine (Intermediate 2) A mixture of 4,6-dichloro-2-methylpyrimidine (505 mg, 3.1 mmol), 3,5-dimethyl-lH-l,2,4- triazole (300 mg, 3.1 mmol) and CS2CO3 (1.54 g, 4.7 mmol) in THF (20 mL) was heated at reflux overnight. The mixture was filtered and the filtrate was concentrated to give 4-chloro-6- (3,5-dimethyl-lH-l,2,4-triazol-l-yl)-2-methylpyrimidine that was used without further purification. MS: m/z = 224.1 (M+H). To a mixture of 4-chloro-6-(3,5-dimethyl-lH-l,2,4-triazol-l-yl)-2-methylpyrimidine (2.00 g, 8.9 mmol), KI (4.44 g, 26.8 mmol) was added 57percent aq. HI solution (20 mL, 89.2 mmol). After heating at 70 ¡ãC for 5 min, water (20 mL) was added to the reaction mixture. The white solid was filtered, rinsed with water, and dried under vacuum to give Intermediate 2 as a white solid. XH NMR (400 MHz, DMSO) delta 8.06 (s, 1H), 2.78 (s, 3H), 2.62 (s, 3H), 2.30 (s, 3H). MS: m/z = 316.1 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dimethyl-4H-1,2,4-triazole, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; MCCOMAS, Casey, C.; REGER, Thomas, S.; WO2014/78216; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics