New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.815588-93-3, name is 1-Methyl-1H-1,2,4-triazole-5-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1-Methyl-1H-1,2,4-triazole-5-carboxylic acid
[00139] To a stirring solution of 7 (0.25 g, 0.88 mmol) in CH2C12 (20 mL) was added HOBt (178 mg, 1.32 mmol), EDCI.HCl (0.2 g, 1.00 mmol) followed by DIPEA (0.4 mL, 2.20 mmol) and Int-C (134 mg, 1.05 mmol) at 0°C. The reaction mixture was stirred at RT for 16 h. After consumption of the starting material (by TLC), the reaction mixture was concentrated under reduced pressure to obtain crude product. This material was purified by column chromatography followed by prep-HP LC purification to afford Compound C (0.07 g, 21percent). 1H-NMR: (500 MHz, DMSO-d6): delta 8.09 (s, 1H), 7.89 (t, 1H), 7.25 (d, 1H), 7.12 (t, 1H), 4.93 (s, 1H), 4.19-4.15 (m, 2H), 4.03 (s, 3H), 3.96-3.91 (m, 4H), 3.44 (d, 1H), 2.25-2.20 (m, 3H), 1.97-1.91 (m, 2H), 1.07 (s, 3H). LCMS (m/z): 394.2 [M++l] HPLC Purity: 93percent
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1-Methyl-1H-1,2,4-triazole-5-carboxylic acid ,and how the biochemistry of the body works.
Reference:
Patent; NAUREX, INC.; LOWE, John, A.; KHAN, M., Amin; WO2014/120800; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics