New learning discoveries about 89292-91-1

The chemical industry reduces the impact on the environment during synthesis 5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine. I believe this compound will play a more active role in future production and life.

89292-91-1, The chemical industry reduces the impact on the environment during synthesis 89292-91-1, name is 5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine, I believe this compound will play a more active role in future production and life.

General procedure: A solution of aminotriazole 11a-m (3.1mmol), glacial acetic acid (5mL), and diethyl ethoxymethylenemalonate (4.6mmol) was refluxed for 3h. After cooling to room temperature, the resulting precipitate was collected by filtration, washed with cold water and dried. The residue was stirred with cold ethyl ether (20mL) and filtered to afford the desired product. Following general procedure C, compound 12k was isolated as a white solid. Yield 78%, mp=220C dec. 1H NMR (200MHz, DMSO-d6) delta: 9.95 (br s, 1H); 8.41 (s, 1H); 4.17-4.07 (q, J=7Hz, 2H); 3.78-3.45 (m, 4H); 2.76 (s, 3H); 2.52-2.49 (m, 4H); 1.26-1.19 (t, J=7.2Hz, 3H)

The chemical industry reduces the impact on the environment during synthesis 5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Aghazadeh Tabrizi, Mojgan; Baraldi, Pier Giovanni; Ruggiero, Emanuela; Saponaro, Giulia; Baraldi, Stefania; Poli, Giulio; Tuccinardi, Tiziano; Ravani, Annalisa; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 11 – 27;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics