New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 956317-36-5
A round bottom flask equipped with magnetic stirrer bar was charged with 5-methyl-2- (2H-1,2,3-triazole-2-yl)benzoic acid (2.0 g, 9.4 mmol, 1 equiv), CH2C12 (94 mL) and hexafluoro isopropanol (1.57 g, 9.4 mmol, 1.0 equiv). After addition of EDC hydrochloride (1.79 g, 9.4 mmol, 1.0 equiv) and DMAP (0.23 g, 1.87 mmol, 0.2 equiv), the reaction mixture was stirred at ambient temperature for 1 h. The solvent was evaporated underreduced pressure followed by purification of the crude product by column chromatography (Si02, cyclohexane /ethyl acetate 50:1). 1,1,1,3,3,3 -hexafluoropropan-2-yl 5 -methyl-2-(2H-1 ,2,3-triazole-2-yl)benzoate (2.5 g, 75%) was obtained as a yellowish oil, which solidifies at 2 C to 4 C.?H NMR (500 MHz, d6-DMSO) oe = 8.08 (s, 2H), 7.81 (d, J = 8.25 Hz, 1H), 7.70 – 7.65 (m, 1H), 7.64 – 7.61 (m, 1H), 6.99 (sept, J = 6.28 Hz, 1H), 2.46 (s, 3H)?3C NMR (125 MHz, CDC13) oe = 163.8, 139.8, 137.2, 135.8, 134.8, 130.5, 134.6, 123.3,120.9 (q, J = 238.3 Hz, (CF3)2), 67.1 (sept, J = 33.5 Hz, OCH(CF3)2), 20.8
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid ,and how the biochemistry of the body works.
Reference:
Patent; SANDOZ AG; HOeFERL-PRANTZ, Kathrin; BARTH, Roland; RICHTER, Frank; ZUPANCIC, Borut; (126 pag.)WO2016/20403; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics