Recommanded Product: 1H-1,2,4-Triazol-5-amine. Ulomskiy, EN; Ivanova, AV; Gorbunov, EB; Esaulkova, IL; Slita, AV; Sinegubova, EO; Voinkov, EK; Drokin, RA; Butorin, II; Gazizullina, ER; Gerasimova, EL; Zarubaev, VV; Rusinov, VL in [Ulomskiy, E. N.; Voinkov, E. K.; Drokin, R. A.; Butorin, I. I.; Rusinov, V. L.] Ural Fed Univ, Dept Organ & Biomol Chem, 19 Mira St, Ekaterinburg 620002, Russia; [Ivanova, A., V; Gazizullina, E. R.; Gerasimova, E. L.] Ural Fed Univ, Dept Analyt Chem, 19 Mira St, Ekaterinburg 620002, Russia; [Ulomskiy, E. N.; Gorbunov, E. B.; Rusinov, V. L.] RAS, Inst Organ Synth, Ural Div, 22-20 S Kovalevskoy St,Akad Skaya St, Ekaterinburg 620990, Russia; [Esaulkova, I. L.; Slita, A., V; Sinegubova, E. O.; Zarubaev, V. V.] Pasteur Inst Epidemiol & Microbiol, 14 Mira St, St Petersburg 197101, Russia published Synthesis and biological evaluation of 6-nitro-1,2,4-triazoloazines containing polyphenol fragments possessing antioxidant and antiviral activity in 2020.0, Cited 33.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
Stable sigma-adducts of azolo[5,1-c]triazines and azolo[1,5-a]pyrimidines with different polyphenols were synthesized and their antioxidant and antiviral activity were investigated. Their affinity to viral hemagglutinin was assessed using molecular modelling. The phloroglucinol-modified azolo-azines possessed the highest virus-inhibiting activity. According to the results of the study of antioxidant properties of compounds, the most promising ones exhibiting highest antioxidant capacity were adducts containing in their structure pyrogallol and catechol residues and 6-nitro-triazolotriazin-7-ol scaffold. No correlation between antioxidant and virus-inhibiting activity of compounds studied was detected. The most active compounds demonstrated the ability to prevent binding of viral hemagglutinin with cellular receptor as shown in hemagglutination inhibition assay. Our results demonstrate that polyphenol-modified azolo-azines are prospective for further optimization as potential antivirals and that their action is directed against viral hemagglutinin.
Recommanded Product: 1H-1,2,4-Triazol-5-amine. Bye, fridends, I hope you can learn more about C2H4N4, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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