New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 61-82-5, name is 1H-1,2,4-Triazol-5-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Safety of 1H-1,2,4-Triazol-5-amine
10108] 144 g (1.714 mol) of 3-amino-i,2,4-triazole (commercial ATA) are added to 1.2 1 of concentrated sulthric acid (98% by weight commercial concentrated sulthric acid) cooled before to 5 C.10109] The mixture is cooled to 5 C. 150 g (2.174 mol) of sodium nitrite (NaNO2) are gradually added at this temperature of 5 C. Care is taken not to exceed 10 C.10110] At the end of the introduction of the sodium nitrite, the reaction medium is gradually heated to 100 C. under a temperature gradient of 12 C/h. Once this temperature of 100 C. is reached (afier approximately 8 hours), the reaction medium is lefi stirring for 2 hours (at said temperature of 100C.).10111] The progression ofthe reaction is monitored by high performance liquid chromatography (HPLC) afier external calibration (using a commercial OTA). The OTA yield is measured on samples withdrawn at different temperatures (diluted in water in order to halt the reaction).10112] FIG. 2 (it is seen that a yield of 100% can be achieved) and the 98% by weight H2504 curve of FIG. 3 werethus drawn up.j0113] This same synthesis and these same measurements were carried out under the same conditions with less concentrated sulfuric acids (see the other two curves of FIG. 3: 44% by weight H2504 and 81% by weight H2504).
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1H-1,2,4-Triazol-5-amine ,and how the biochemistry of the body works.
Reference:
Patent; HERAKLES; EURENCO; HERVE, Gregoire; JACOB, Guy; CAGNON, Guy; BOUCHEZ, Jean-Marc; (9 pag.)US2016/46588; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics