New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 60166-43-0, name is 1,4-Dimethyl-1H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 1,4-Dimethyl-1H-1,2,3-triazole
The compound 1G (1.02 g, 1.9 mmol), 1,4-dimethyl-1H-1,2,3-triazole (380 mg, 3.8 mmol) obtained in the previous step,Tetramethylammonium acetate (251mg, 1.9mmol) and PdCl2 (PPh 3) 2 (bistriphenylphosphonium palladium dichloride) (100mg, 0.14mmol) were added to DMF (20mL) and the air was replaced with nitrogen, then protected under nitrogen Then, stir at 100 degrees overnight.After TLC showed that the reaction was over, the reaction was cooled to room temperature, poured into 200 ml of water, and extracted with ethyl acetate (2 × 100 mL).The combined organic phases were washed with a saturated sodium chloride solution (3 × 100 mL), the organic phases were dried over anhydrous sodium sulfate,The desiccant was removed by filtration, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 3: 1 to 1: 1 (volume ratio V: V)),The target product Compound 1H (430 mg, yellow solid) was obtained in a yield of 42%.
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Reference:
Patent; Wuhan Yukeyuan Pharmaceutical Biological Technology Co., Ltd.; Fang Huaxiang; Yu Bin; Li Fangfang; Zhang Xiaolin; Che Peng; Xu Yong; (18 pag.)CN110357878; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics