New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 930-33-6, name is 1H-1,2,4-Triazol-3(2H)-one belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1H-1,2,4-Triazol-3(2H)-one
To a solution of 29 (2.0g, 23.5mmol, 1.0 equiv.) in DCM (20mL), (BOC)2O (5.1g, 23.5mmol, 1.0 equiv.), DMAP (0.287g, 2.35mmol, 0.1 equiv.) and DIPEA (10.0mL, 58.7mmol, 2.5 equiv.) were added. The reaction was stirred at room temperature for 18h. The reaction mixture was concentrated under reduced pressure and purified by flash chromatography using DCM/MeOH (20:1, v/v) as mobile phase. Yield, 14%. 1H NMR (400MHz, DMSO-d6) delta 1.50 (s, 9H), 7.98 (s, 1H) ppm. 13C NMR (100MHz, DMSO-d6) delta 27.97, 85.83, 136.53, 147.15, 153.68ppm. ESI-MS for C7H11N3O [M-H]- 184.12.
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Reference:
Article; Fonovi?, Ur?a Pe?ar; Knez, Damijan; Hrast, Martina; Zidar, Nace; Proj, Matic; Gobec, Stanislav; Kos, Janko; European Journal of Medicinal Chemistry; vol. 193; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics