Total Synthesis of Chloptosin was written by Oelke, Alexander J.;France, David J.;Hofmann, Tatjana;Wuitschik, Georg;Ley, Steven V.. And the article was included in Angewandte Chemie, International Edition in 2010.SDS of cas: 156311-83-0 The following contents are mentioned in the article:
Total synthesis of chloptosin has been achieved in 30 steps (17 steps in the longest linear sequence) and in 4 % overall yield from azodicarboxylate. Especially pleasing, during this work we developed a versatile enantioselective organo-catalytic route to piperazic acids that employs a new differentially substituted (Boc and Troc) azodicarboxylate, to generate orthogonally protected piperazic acid building blocks in multigram quantities in a short and efficient sequence (> 80 % from cheap com. achiral starting materials). Furthermore, a Stille reaction was used successfully to couple two sterically demanding o-chloropyrroloindoles. Following this readily modifiable route, a new generation of analogs for biol. testing can be realized that could provide valuable new information concerning the mechanism of action of this structurally interesting mol. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0SDS of cas: 156311-83-0).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.SDS of cas: 156311-83-0
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics