The author of 《Preparation of multifunctional glycopolymers using double orthogonal reactions and the effect of electrostatic groups on the glycopolymer-lectin interaction》 were Oh, Takahiro; Jono, Kazuki; Kimoto, Yuri; Hoshino, Yu; Miura, Yoshiko. And the article was published in Polymer Journal (Tokyo, Japan) in 2019. Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The author mentioned the following in the article:
We investigated synthetic biomacromols. to control mol. interactions. Multifunctional glycopolymers for mol. recognition were prepared via living radical polymerization and post-click chem. with orthogonal Huisgen and thiol-epoxy reactions. The synthesis of the polymer backbone and the subsequent side-chain introduction successfully proceeded in high yield. The multifunctional glycopolymers had a tri-block structure: the first and third blocks contained mannose, and the second block contained either a pos. or neg. charged group or a neutral hydrophilic group. The mol. recognition of the glycopolymers toward lectin was evaluated via fluorescence quenching measurements. Because of the electrostatic interaction, the binding constant varied in the following order: pos. charged glycopolymer (PT110) > neg. charged glycopolymer (NT110). The effect of the electrostatic interactions was modest compared with the effect of the carbohydrate-lectin binding. These results suggested that the carbohydrate-lectin interaction was an important factor in the mol. recognition of glycopolymers. This study provides guidelines for the preparation of multifunctional polymers, such as biomaterials.Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine) was used in this study.
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics