Related Products of 288-36-8, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 288-36-8, name is 1H-1,2,3-Triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1H-1, 2, 3-triazole (10 g, 145 mmol) in anhydrous THF (150 mL) was added powder K2CO3(40.0g, 290 mmol) , then iodomethane (32.29 g, 227 mmol) was added dropwise at 30 . After the addition was complete, the mixture was stirred at 30 for 16 h. The reaction mixture was filtered and the filtrate was concentrated to afford the product as an oil.1H-NMR: (DMSO-d6400MHz) delta 8.06 (s, 1H) , 7.71 (s, 1H) , 4.05 (s, 3H)
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 1H-1,2,3-Triazole, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ARASAPPAN, Ashok; BUNGARD, Christopher James; FRIE, Jessica L.; HAN, Yongxin; HOYT, Scott B.; MANLEY, Peter J.; MEISSNER, Robert S.; PERKINS, James; SEBHAT, Iyassu K.; WILKENING, Robert R.; (140 pag.)WO2016/29454; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics