Our Top Choice Compound: 3222-47-7

In addition to the literature in the link below, there is a lot of literature about this compound(6-Methylnicotinic acid)Product Details of 3222-47-7, illustrating the importance and wide applicability of this compound(3222-47-7).

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Generating Multibillion Chemical Space of Readily Accessible Screening Compounds, published in 2020-11-20, which mentions a compound: 3222-47-7, Name is 6-Methylnicotinic acid, Molecular C7H7NO2, Product Details of 3222-47-7.

An approach to the generation of ultra-large chem. libraries of readily accessible (‘REAL’) compounds is described. The strategy is based on the use of two- or three-step three-component reaction sequences and available starting materials with pre-validated chem. reactivity. After the preliminary parallel experiments, the methods with at least ~80% synthesis success rate (such as acylation – deprotection – acylation of monoprotected diamines e.g., 1-boc-amino-butyl-3-amine or amide formation e.g., N-(9-acetyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide – click reaction with functionalized azides e.g., 3-(azidomethyl)-piperidine) can be selected and used to generate the target chem. space. It is shown that by using only on the two aforementioned reaction sequences, a nearly 29-billion compound library is easily obtained. According to the predicted physico-chem. descriptor values, the generated chem. space contains large fractions of both drug-like and ‘beyond rule-of-five’ members, whereas the strictest lead-likeness criteria (the so-called Churcher’s rules) are met by the lesser part, which still exceeds 22 million.

In addition to the literature in the link below, there is a lot of literature about this compound(6-Methylnicotinic acid)Product Details of 3222-47-7, illustrating the importance and wide applicability of this compound(3222-47-7).

Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics