Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 584-13-4, name is 4H-1,2,4-Triazol-4-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 584-13-4
5-(4J-l,2,4-Triazol”4-ylamino)-4I-(beiizyIoxy)biphenyl-2-carbonitriIe (CAB06050)To a solution of 4/?-l,2,4-triazol-4-amine (2.439 g, 29.01 mmol) in DMSO (50 mL) was added KOtBu (336 g, 30.0 mmol). The mixture was stirred for 0.5 hours at room temperature before CAB06Theta48 (4.40 g, 14.51 mmol) was added and stirring was continued for 1 hour. The mixture was poured into crashed ice and neutralized with 2M BCHSO4 solution. The precipitate was filtered off and recrystallised from EtOAc/«-hexane to give CAB06050 (5.07 g, 85%) as fine colorless needles. Mp. 180-182 0C; 1H NMR (400 MHz, DMSO-rftf) delta 5.17 (s, 2H)5 6.47 (d, J = 2.4 Hz5 IH), 6.54 (dd, J = 8.6, 2.4 Hz, IH)5 7.15 (AA’BB’, 2H), 732-7.50 (m, 7H)5 7.78 (d, J= 8.6 Hz, IH), 8.86 (s, 2H), 10.28 (S5 IH); 13C NMR (100.6 MHz5 DMSO-rf*) delta 69.4, 101.2, 111.0, 1123, 115.0, 119.1, 127,8, 127.9, 128.5, 129.7, 130.2, 135.6, 136.8, 144.1, 146.0, 150.8, 158.9; LRMS (ES+): m/z 368,2 (100%, [M+H]+); HRMS (ES+) calcd for C22H18N5O [M+H]+: 368.1506, found 368.1494.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4H-1,2,4-Triazol-4-amine, in my other articles.
Reference:
Patent; STERIX LIMITED; WOO, Lok Wai Lawrence; BUBERT, Christian; WOOD, Paul Michael; PUTEY, Aurelien; PUROHIT, Atul; POTTER, Barry Victor Lloyd; WO2011/23989; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics