Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 956317-36-5
Example 5: Preparation of Compound 5 (S)-(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)(5-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-6-azaspiro[2.5]octan-6-yl)methanone; [Show Image] 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid (1eq; prepared according to WO 2008147518), HOBT (1 eq) and EDCl.HCl (1.5eq) dissolved in dichloromethane (5ml/mmol) were stirred at 25C for 0.5-2hours, then intermediate 2 (1 eq) dissolved in dichloromethane was added. After 18 hours the mixture was poured in an aqueous saturated solution of NaHCO3 and extracted with dichloromethane. The crude was purified by silica gel column chromatography (DCM to DCM/MeOH = 9/1) to obtain the title compound with yield of 52%. 1 HNMR (CDCl3) delta ppm 8.22-8.38 (m, 1 H), 7.94-8.14 (m, 1 H), 7.79-7.86 (m, 1 H), 7.69 (m, 1 H), 7.50-7.62 (m, 1 H), 7.28-7.37(m, 1 H), 7.0-7.24(m, 1 H), 6.48-6.66 (m, 1 H), 5.20(m, 1 H), 4.34-4.84 (m, 1 H), 3.89-4.0 (m, 1 H),3.65-3.75 (m, 1 H), 3.21-3.44 (m, 2H), 3.01-3.11 (m, 1 H), 2.26-2.46 (m, 3H), 1.89-2.17 (m, 1 H), 1.02-1.28 (m, 1 H), 0.19-0.63(m, 4H) MS= ESI + m/z 439 [M+H]+
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 956317-36-5.
Reference:
Patent; ROTTAPHARM S.P.A.; EP2484674; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics