Synthetic Route of 1533519-85-5, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, molecular formula is C18H17N3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
32 g of methyl 2-(4-(4-cyclopropyl-1-naphthyl)-4hydro-1,2,4-triazol-3-ylsulfanyl)acetate are placedIn a 10L flask, 600 mL of acetonitrile and 20 mL of pyridine were added, and the mixture was stirred and dissolved. After the solution was completely dissolved, the mixture was dropped at a rate of 10 mL/min.90mL of a 1mol/L Bromine Br2-acetonitrile solution was added dropwise at room temperature for 2 hours. After the reaction was complete, 2L of B was added to the reaction.Ethyl acetate was dissolved, washed twice with saturated brine, and washed with 1 L each time. The organic phase was collected and dried over saturated sodium sulfate.Concentrate and filter to obtain methyl 2-(5-bromo-4-(4-cyclopropyl-1-naphthyl)-4hydro-1,2,4triazol-3-ylsulfanyl)acetate.34.5 g, yield 87.3%; purity 98.2%.
I am very proud of our efforts over the past few months and hope to Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate help many people in the next few years.
Reference:
Patent; Chengdu Meiyugao Pharmaceutical Co., Ltd.; Wang Chunyan; Chen Zhiyong; Sui Yumin; (17 pag.)CN107955029; (2018); A;,
1,2,3-Triazole – Wikipedia,
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