Triazoles

Alkaline cation directed structural diversity of cubic-cage-based cobalt(II) metal-organic frameworks: from pcu to bct net was written by Zou, Ji-Yong;Shi, Wei;Zhang, Jing-Ya;He, Yan-Fei;Gao, Hong-Ling;Cui, Jian-Zhong;Cheng, Peng. And the article was included in CrystEngComm in 2014.Product Details of 4546-95-6 This article mentions the following:

Three 2p-3d heterometallic cubic-cage-based metal-organic frameworks (MOFs), formulated as {[H₂N(CH₃)₂]₉(H₃O)₆[Co(H₂O)₆][Co₈Li₃(TDA)₁₂]·14H₂O}_n (1), {(H₃O)₁₅[Co(H₂O)₆][Co₈Li₃(TDA)₁₂]·10H₂O}_n (2) and {[H₂N(CH₃)₂](H₃O)₁₆[Co₈K₅(μ₂-O)(TDA)₁₂(H₂O)₂]·10H₂O}_n (3) (H₃TDA = 1H-1,2,3-triazole-4,5-dicarboxylic acid), have been successfully synthesized and structurally characterized. In these 2p-3d heterometallic cubic-cage-based MOFs, eight Co²⁺ cations as the vertexes are interconnected by twelve TDA^3- ligands as the edges to form an unusual [Co₈(TDA)₁₂]^20- cubic cage with edges of 6.12 Å, in which a hexahydrated Co²⁺ ion is captured for 1 and 2. The neighboring [Co₈(TDA)₁₂]^20- cubic cages are further bridged by Li⁺ ions for 1 and 2 and K⁺ ions for 3 to give 3D 6-connected pcu nets for 1 and 2 and a 10-connected bct net for 3. The magnetic properties of 1–3 were studied. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Product Details of 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.Product Details of 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Controllable porosity conversion of metal-organic frameworks composed of natural ingredients for drug delivery was written by Liu, Jiang;Bao, Tian-Yi;Yang, Xi-Ya;Zhu, Pei-Pei;Wu, Lian-He;Sha, Jing-Quan;Zhang, Lei;Dong, Long-Zhang;Cao, Xue-Li;Lan, Ya-Qian. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Electric Literature of C4H3N3O4 This article mentions the following:

Two extremely rare β-cyclodextrin (β-CD) supported metal-organic frameworks (MOFs), CD-MOF-1 and CD-MOF-2, were induced to crystallize for the first time through a template-induced approach. The targeted CD-MOFs were employed to perform controlled drug delivery and cytotoxicity assays that confirmed their favorable biol. potential of being used as drug carriers. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Electric Literature of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Electric Literature of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In vitro metabolism of oprozomib, an oral proteasome inhibitor: role of epoxide hydrolases and cytochrome P450s was written by Wang, Zhican;Fang, Ying;Teague, Juli;Wong, Hansen;Morisseau, Christophe;Hammock, Bruce D.;Rock, Dan A.;Wang, Zhengping. And the article was included in Drug Metabolism & Disposition in 2017.Recommanded Product: 1614-12-6 This article mentions the following:

Oprozomib is an oral proteasome inhibitor currently under investigation in patients with hematol. malignancies or solid tumors. Oprozomib elicits potent pharmacol. actions by forming a covalent bond with the active site N-terminal threonine of the 20S proteasome. Oprozomib has a short half-life across preclin. species and in patients due to systemic clearance via metabolism Potential for drug-drug interactions (DDIs) could alter the exposure of this potent therapeutic; therefore, a thorough investigation of pathways responsible for metabolism is required. In the present study, the major drug-metabolizing enzyme responsible for oprozomib metabolism was identified in vitro. A diol of oprozomib was found to be the predominant metabolite in human hepatocytes, which formed via direct epoxide hydrolysis. Using recombinant epoxide hydrolases (EHs) and selective EH inhibitors in liver microsomes, microsomal EH (mEH) but not soluble EH (sEH) was found to be responsible for oprozomib diol formation. Coincubation with 2-nonylsulfanyl-propionamide, a selective mEH inhibitor, resulted in a significant decrease in oprozomib disappearance (>80%) with concurrent complete blockage of diol formation in human hepatocytes. On the contrary, a selective sEH inhibitor did not affect oprozomib metabolism Pretreatment of hepatocytes with the pan-cytochrome P 450 (P 450) inhibitor 1-aminobenzotriazole resulted in a modest reduction (∼20%) of oprozomib metabolism These findings indicated that mEH plays a predominant role in oprozomib metabolism Further studies may be warranted to determine whether drugs that are mEH inhibitors cause clin. significant DDIs with oprozomib. On the other hand, pharmacokinetics of oprozomib is unlikely to be affected by coadministered P 450 and sEH inhibitors and/or inducers. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Recommanded Product: 1614-12-6).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRecommanded Product: 1614-12-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Syntheses and crystal structures of copper(II) and nickel complexes with 1,2,3-triazole-carboxylic acid was written by Wang, Duo-Zhi;Bai, Mei;Zhang, Jian-Bin;Ma, Peng-Yuan. And the article was included in Chinese Journal of Structural Chemistry in 2012.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

Three novel complexes [Cu(L¹)₂(H₂O)₂] (1), [Ni(L¹)₂(H₂O)₂]·(H₂O)₄ (2, HL¹ = 5-methyl-1-(4-methylphenyl)-1,2,3-triazole-4-carboxylic acid) and [Ni₂(HL²)₂(CH₃OH)₆]·(CH₃OH)₂ (3, H₃L² = 1,2,3-triazole-4,5-dicarboxylic acid) were synthesized and characterized by elemental anal., IR and x-ray diffraction. Complexes 1 and 2 are mononuclear structures, and are assembled into a two-dimensional sheet by C(7)-H(7)···O(3) weak interactions or hydrogen-bonding interaction. Complex 3 is a centrosym. dinuclear structure, and is assembled into a three-dimensional supramol. structure by hydrogen-bonding interaction. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Safety of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

catena-Poly[(chloridozinc)-μ-5-(1-methyl-1H-benzimidazol-2-yl-κN³)-1,2,3-triazol-1-ido-κ²N¹:N³] was written by Sun, Chen-Guang;Song, Ji-Rong. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid This article mentions the following:

In the title complex, [Zn(C₁₀H₈N₅)Cl]_n, the Zn^II ion is four-coordinated by one Cl atom and three N atoms from two in situ-generated deprotonated 5-(1-methyl-1H-benzimidazol-2-yl-κN³)-1,2,3-triazol-1-ide ligands in a slightly distorted tetrahedral geometry. The Zn^II ions are bridged by the ligands, forming a helical chain along [001]. C-H···N and C-H···Cl H bonds and π-π interactions between the imidazole rings [centroid-centroid distance = 3.4244(10) Å] assemble the chains into a three-dimensional supramol. network. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Application In Synthesis of 1H-1,2,3-Triazole-4,5-dicarboxylic acid

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Syntheses of D-arabinofuranosyl and 2′-deoxy-D-ribofuranosyl 1,2,3-triazolecarboxamides was written by Makabe, Osamu;Suzuki, Hiroshi;Umezawa, Sumio. And the article was included in Bulletin of the Chemical Society of Japan in 1977.Recommanded Product: 40594-98-7 This article mentions the following:

Several D-arabino- and 2′-deoxy-D-ribonucleosides of 1,2,3-triazolecarboxamides were synthesized by 2 methods, one involving acid-catalyzed fusion reactions of 1-O-acetyl-2,3,5-tri-O-benzyl-D-arabinofuranose or 1-O-acetyl-3,5-di-O-(p-nitrobenzoyl)-D-2-deoxyribofuranose with Et 1,2,3-triazole-4-carboxylate (I), and the other by glycosylation of the trimethylsilyl derivative of I with 2,3,5-tri-O-benzyl-D-arabinofuranosyl chloride or 3,5-di-O-(p-toluoyl)-D-2-deoxyribofuranosyl chloride. Evidence for the N-glycosylation sites (1 or 2 of triazole) and anomeric configurations of the resulting nucleosides is presented. Of the compounds prepared nucleosides II (R = H, OH) showed antiviral and cytotoxic activities (no data). In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7Recommanded Product: 40594-98-7).

Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. The many free lone pairs in triazoles make them useful as coordination compounds, although not typically as haptic ligands. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Recommanded Product: 40594-98-7

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Virtual Combinatorial Syntheses and Computational Screening of New Potential Anti-Herpes Compounds was written by de Julian-Ortiz, Jesus V.;Galvez, Jorge;Munoz-Collado, Carlos;Garcia-Domenech, Ramon;Gimeno-Cardona, Concepcion. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 4546-95-6 This article mentions the following:

The activity of new anti-HSV-1 chem. structures, designed by virtual combinatorial chem. synthesis and selected by a computational screening, is determined by an in vitro assay. A virtual library of phenol esters and anilides was formed from two databases of building blocks: one with carbonyl fragments and the other containing both substituted phenoxy and phenylamino fragments. The library of virtually assembled compounds was computationally screened, and those compounds which were selected by our math. model as active ones were finally synthesized and tested. Our antiviral activity model is a “tandem” of four linear functions of topol. graph-theor. descriptors. A given chem. structure was selected as active if it satisfies every discriminant equation in that model. The final result was that five new structures were selected, synthesized, and tested: all of them demonstrated activity, and three showed appreciable anti-HSV-1 activity, with IC₅₀ values of 0.9 μM. The same model, applied to a database of known compounds, has identified the anti-herpes activity of the following compounds: 3,5-dimethyl-4-nitroisoxazole, nitrofurantoin, 1-(pyrrolidinocarbonylmethyl)piperazine, nebularine, cordycepin, adipic acid, thymidine, α-thymidine, inosine, 2,4-diamino-6-(hydroxymethyl)pteridine, 7-(carboxymethoxy)-4-methylcoumarin, 5-methylcytidine, and others that showed less activity. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6HPLC of Formula: 4546-95-6).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.HPLC of Formula: 4546-95-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

3,4-Diamino-1,2,4-triazole based energetic salts: synthesis, characterization, and energetic properties was written by Wu, Jin-Ting;Zhang, Jian-Guo;Yin, Xin;Cheng, Zi-Yuan;Xu, Cai-Xia. And the article was included in New Journal of Chemistry in 2015.Synthetic Route of C4H3N3O4 This article mentions the following:

The protonation or metathesis synthesis and energetic properties of a new class of energetic materials, energetic salts of 3,4-diamino-triazole (DATr), are described. They were characterized by Fourier transform IR spectroscopy (FT-IR), elemental anal. (EA), differential scanning calorimetry (DSC), and X-ray single-crystal diffraction. The DSC results showed that these salts had acceptable thermal stabilities; the decomposition temperatures of these salts, except compound 3,4-Diamino-1,2,4-triazoliumnitro-formate, were over 200°. The d. of the series of salts ranged from 1.704 (3,4-Diamino-1,2,4-triazolium nitrate and 3,4-Diamino-1,2,4-triazolium picrate)-1.82 g cm^-3 (3,4-Diamino-1,2,4-triazolium trinitrophloroglucinate), placing them in a class of relatively dense compounds, and the heats of formation were calculated with the Gaussian 03 suite of programs. All the salts except 3,4-Diamino-1,2,4-triazolium 4,5-dicarboxylic-1,2,3-triazolate exhibited promising detonation performances (detonation pressure: 21.5-32.8 GPa, detonation velocity: 7017-8620 m s^-1), which were much higher than both those of TNT, and salt 3,4-Diamino-1,2,4-triazoliumnitro-formate was even comparable to RDX. Impact sensitivities were also determined by hammer tests and the results ranged from 8 J (sensitive) to > 40 J (insensitive). In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6Synthetic Route of C4H3N3O4).

1H-1,2,3-Triazole-4,5-dicarboxylic acid (cas: 4546-95-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Synthetic Route of C4H3N3O4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP was written by Yamane, Mizuki;Kawashima, Kosuke;Yamaguchi, Koji;Nagao, Shunsuke;Sato, Mika;Suzuki, Masayuki;Honda, Kiyofumi;Hagita, Hitoshi;Kuhlmann, Olaf;Poirier, Agnes;Fowler, Stephen;Funk, Christoph;Simon, Sandrine;Aso, Yoshinori;Ikeda, Sachiya;Ishigai, Masaki. And the article was included in Xenobiotica in 2015.Formula: C6H6N4 This article mentions the following:

1. The metabolism and drug-drug interaction (DDI) risk of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, were evaluated by in vitro studies using human liver microsomes, human hepatocytes, and recombinant human CYPs. 2. The main metabolite of tofogliflozin was the carboxylated derivative (M1) in human hepatocytes, which was the same as in vivo. The metabolic pathway of tofogliflozin to M1 was considered to be as follows: first, tofogliflozin was catalyzed to the primary hydroxylated derivative (M4) by CYP2C18, CYP4A11 and CYP4F3B, then M4 was oxidized to M1. 3. Tofogliflozin had no induction potential on CYP1A2 and CYP3A4. Neither tofogliflozin nor M1 had inhibition potential on CYPs, with the exception of a weak CYP2C19 inhibition by M1. 4. Not only are multiple metabolic enzymes involved in the tofogliflozin metabolism, but the drug is also excreted into urine after oral administration, indicating that tofogliflozin is eliminated through multiple pathways. Thus, the exposure of tofogliflozin would not be significantly altered by DDI caused by any co-administered drugs. Also, tofogliflozin seems not to cause significant DDI of co-administered drugs because tofogliflozin has no CYP induction or inhibition potency, and the main metabolite M1 has no clin. relevant CYP inhibition potency. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Formula: C6H6N4).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeFormula: C6H6N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The 2-hydroxyiminostilbene metabolite of carbamazepine or the supernatant from incubation of hepatocytes with carbamazepine activates inflammasomes: implications for carbamazepine-induced hypersensitivity reactions was written by Kato, Ryuji;Ijiri, Yoshio;Hayashi, Tetsuya;Uetrecht, Jack. And the article was included in Drug Metabolism & Disposition in 2019.Computed Properties of C6H6N4 This article mentions the following:

In the present study, we investigated whether carbamazepine induces the release of DAMPs by using human hepatocarcinoma functional liver cell-4 (FLC-4) cells for bioactivation of carbamazepine. THP-1 cells, a human macrophage cell line, were used for detecting inflammasome activation. We found that increased caspase-1 activity and production of interleukin-1b by THP-1 cells were caused by the supernatant from the incubation of carbamazepine with FLC-4 cells. In the supernatant, heat shock protein 60 was significantly increased. In addition, 2-hydroxyiminostilbene, which is a metabolite of carbamazepine, activated inflammasomes. These results suggest that the reactive iminoquinone metabolite can directly activate inflammasomes or that stressed hepatocytes cause the release of DAMPs, which are responsible for inflammasome activation. The activation of inflammasomes may be an important step in the immune system activation by carbamazepine, which can lead to hypersensitivity reactions in some patients. In the experiment, the researchers used many compounds, for example, 1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6Computed Properties of C6H6N4).

1H-Benzo[d][1,2,3]triazol-1-amine (cas: 1614-12-6) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides. Due to the structural characteristics, both 1,2,3- and 1,2,4-triazoles are able to accommodate a broad range of substituents (electrophiles and nucleophiles) around the core structures and pave the way for the construction of diverse novel bioactive molecules.Computed Properties of C6H6N4

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics