In 2019,Environmental Science and Pollution Research included an article by Pelizaro, Bruno Ivo; Braga, Felipe Camargo; Crispim, Bruno do Amaral; de Barros, Luiz Guilherme Maiolino Lacerda; Pessatto, Lucas Roberto; Oliveira, Edwin Jose Torres; Vani, Juliana Miron; de Souza, Antonio Pancracio; Grisolia, Alexeia Barufatti; Antoniolli-Silva, Andreia Conceicao Milan Brochado; de Lima, Denis Pires; dos Santos Jaques, Jeandre Augusto; Beatriz, Adilson; Oliveira, Rodrigo Juliano. Quality Control of 1H-1,2,3-Triazole. The article was titled 《Assessment of acute toxicity and cytotoxicity of fluorescent markers produced by cardanol and glycerol, which are industrial waste, to different biological models》. The information in the text is summarized as follows:
The amphyphylic triazoanilines recently synthesized 1-(4-(3-aminophenyl)-1H-1,2,3- triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (1) and 1-(4-(4-aminophenyl)-1H- 1,2,3-triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (2), synthesized from cardanol and glycerol, have photophys. properties which allow their use in the development of fluorescent biomarkers with applicability in the biodiesel quality control. Based on this, the present research evaluated the toxic effects of both compounds in different biol. models through the investigation of survival and mortality percentages as a measure of acute toxicity on Daphnia similis and Oreochromis niloticus, larvicidal assay against Aedes aegypti, and cytotoxic activity on mammary cells. Results demonstrate that these triazoanilines 1 and 2 have shown low acute toxicity to the biol. models investigated in this study up to the following concentrations: 4.0 mg L-1 (D. similis), 4.0 mg L-1 (A. aegypti larvae), 1.0 mg L-1 (O. niloticus), and 1.0 mg mL-1 (mammary cells). This fact suggests the potential for safe use of compounds 1 and 2 as fluorescent markers for the monitoring of biodiesel quality, even in the case of environmental exposure. Besides all of that, the reuse of cardanol and glycerol, both industrial wastes, favors the maintenance of environmental health and is in agreement with the assumptions of green chem. The experimental process involved the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Quality Control of 1H-1,2,3-Triazole)
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Quality Control of 1H-1,2,3-Triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics