Name: 1H-1,2,3-TriazoleIn 2021 ,《Azole as privileged heterocycle for targeting the inducible cyclooxygenase enzyme》 appeared in Drug Development Research. The author of the article were Prasher, Parteek; Sharma, Mousmee. The article conveys some information:
A review. An over-expression of COX-2 isoenzyme belonging to the Cyclooxygenase Enzyme Family triggers the overproduction of pro-inflammatory prostaglandins that instigate the development of chronic inflammation and related disorders. Hence, the rationally designed drugs for mitigating over-activity of COX-2 isoenzyme play a regulatory role toward the alleviation of the progression of these disorders. However, a selective COX-2 inhibition chemotherapy prompts several side effects that necessitate the identification of novel mol. scaffolds for deliberating state-of-the-art drug designing strategies. The heterocyclic “”azole”” scaffold, being polar and hydrophilic, possesses remarkable physicochem. advantages for designing physiol. active mols. capable of interacting with a wide range of biol. components, including enzymes, peptides, and metabolites. The substituted derivatives of azole nuclei enable a comprehensive SAR anal. for the appraisal of bioactive profile of the deliberated mols. for obtaining the rationally designed compounds with prominent activities. The comprehensive SAR anal. readily prompted the identification of Y-shaped mols. and the eminence of bulkier group for COX-2 selective inhibition. This review presents an epigrammatic collation of the pharmacophore-profile of the chemotherapeutics based on azole motif for a selective targeting of the COX-2 isoenzyme. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics